Polyphosphazenes: effect of molecular motions on thrombogenesis.

نویسندگان

  • W M Reichert
  • F E Filisko
  • S A Barenberg
چکیده

The effect and interrelationship between primary (segmental backbone) and secondary (side chain) molecular motions on thrombogenesis, independent of morphological order/disorder, crystallinity, and/or associated water is elucidated using an amorphous hydrophobic polymer of poly-[(trifluoroethoxy) (fluoroalkoxy)phosphazene] PNF. The results indicate that thrombogenesis for an amorphous hydrophobic polymer is sensitive and dependent on the degrees and types of primary and secondary molecular motions at the polymer interface.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Thrombogenesis: an epitaxial phenomena. I.

A semiempirical epitaxial model has been derived which correlates and interrelates the surface free energy, ultrastructural morphology, surface charge, surface chemistry, and surface molecular motions of a model triblock copolymer to thrombogenesis. This paper addresses the aspect of: (1) ultrastructure order versus disorder, (2) primary and secondary molecular motions, (3) surface and side cha...

متن کامل

Preparation of polyphosphazenes: a tutorial review

Poly(organo)phosphazenes are a family of inorganic molecular hybrid polymers with very diverse properties due to the vast array of organic substituents possible. This tutorial review aims to introduce the basics of the synthetic chemistry of polyphosphazenes, detailing for readers outside the field the essential knowledge required to design and prepare polyphosphazenes with desired properties. ...

متن کامل

Polyphosphazenes: Multifunctional, Biodegradable Vehicles for Drug and Gene Delivery

Poly[(organo)phosphazenes] are a unique class of extremely versatile polymers with a range of applications including tissue engineering and drug delivery, as hydrogels, shape memory polymers and as stimuli responsive materials. This review aims to divulge the basic principles of designing polyphosphazenes for drug and gene delivery and portray the huge potential of these extremely versatile mat...

متن کامل

Chain-End-Functionalized Polyphosphazenes via a One-Pot Phosphine-Mediated Living Polymerization

A simple polymerization of trichlorophosphoranimine (Cl3 P = N-SiMe3 ) mediated by functionalized triphenylphosphines is presented. In situ initiator formation and the subsequent polymerization progress are investigated by (31) P NMR spectroscopy, demonstrating a living cationic polymerization mechanism. The polymer chain lengths and molecular weights of the resulting substituted poly(organo)ph...

متن کامل

Polyphosphazenes Enhance Mucosal and Systemic Immune Responses in Mice Immunized Intranasally with Influenza Antigens

Polyphosphazenes are synthetic, biodegradable, water-soluble polymers with a great versatility for vaccine and drug delivery applications. We previously observed that polyphosphazenes enhance immune responses in mice when injected subcutaneously against X:31 influenza antigens. Here, we investigated the potential of polyphosphazenes as mucosal adjuvants for enhancing influenza-specific immune r...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of biomedical materials research

دوره 16 3  شماره 

صفحات  -

تاریخ انتشار 1982